APA
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Williams-Jones, D. P., Webby, M. N., Press, C., Gradon, J. M., Armstrong, S. R., Szczepaniak, J., & Kleanthous, C. (2023). Tunable force transduction through the Escherichia coli cell envelope. Proceedings of the National Academy of Sciences of the United States of America.
Chicago/Turabian
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Williams-Jones, Daniel P., M. N. Webby, Cara Press, Jan M. Gradon, Sophie R. Armstrong, J. Szczepaniak, and Colin Kleanthous. “Tunable Force Transduction through the Escherichia Coli Cell Envelope.” Proceedings of the National Academy of Sciences of the United States of America (2023).
MLA
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Williams-Jones, Daniel P., et al. “Tunable Force Transduction through the Escherichia Coli Cell Envelope.” Proceedings of the National Academy of Sciences of the United States of America, 2023.
BibTeX Click to copy
@article{daniel2023a,
title = {Tunable force transduction through the Escherichia coli cell envelope},
year = {2023},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
author = {Williams-Jones, Daniel P. and Webby, M. N. and Press, Cara and Gradon, Jan M. and Armstrong, Sophie R. and Szczepaniak, J. and Kleanthous, Colin}
}
Significance The outer membrane (OM) of Gram-negative bacteria is a major factor in the antimicrobial resistance crisis. The Tol system is a conserved assembly that exploits the energised inner membrane to stabilise the OM of these bacteria. System defects result in a destabilised OM and increased antibiotic susceptibility. We report the structure of the Tol motor complex, which, by comparison to other motors, supports rotation as the means of force generation. We also demonstrate that the degree of stabilising mechanical force from the motor can be modified by varying the structure of the force-transducing protein that connects the two membranes.